The Stem Cells That Sleep Inside You — Until They’re Needed Most

The story begins on the edge of a forest, 10,000 years ago.

You’ve just been mauled by a bear. Your leg is torn open. Flesh is missing. Bones exposed. Infection is a risk — but you survive.

How? To rebuild damaged tissue — skin, muscle, even bone — your body had to deploy its most powerful repair system. Not a patch job. A full rebuild.

And to do that, it needed something special: Cells that could become anything. Cells that could rebuild as if nothing had ever been damaged. Cells that still exist in your body — right now. These are VSELs: Very Small Embryonic-Like Stem Cells. They are pluripotent, age-resistant, and completely under the radar of modern medicine.

Until now.

What Are VSELs?

VSELs are a rare population of naturally occurring pluripotent stem cells found in your own blood. Let’s break that down:

Pluripotent

They carry the ability to become any type of tissue in the body — skin, muscle, neurons, cartilage, liver, even heart cells. Not just one lineage. All three germ layers: ectoderm, mesoderm, and endoderm.

Age-Resistant

Unlike other stem cells that degrade or lose potency with age (like mesenchymal stem cells), VSELs show no signs of biological aging. They retain their “youthful” characteristics no matter how old you are.

Ultra-Small

They’re only 1-2 microns in diameter — so small they don’t get trapped in the lungs like larger stem cells (a problem called “pulmonary first-pass effect”). That means they can circulate freely through your bloodstream and potentially reach places like the brain, joints, and bone marrow.

Dormant

They lie dormant in healthy adults. Why? Because your body only calls them in when things get serious — like bear-attack serious. Trauma. Survival-level stress.

Can You Wake Them Up?

We know that certain extreme conditions — like prolonged fasting, hyperbaric oxygen therapy, intense physical training, cold exposure (such as ice baths), or even physical trauma — can mobilize VSELs into the bloodstream. These events signal to the body that something serious is happening, something that might require deep, cellular repair.

But here’s the crucial distinction: mobilization isn’t activation.

Just because more VSELs are circulating doesn’t mean they’re doing anything. They remain in a dormant state — silent, passive, waiting. And until recently, no one had demonstrated a reliable way to activate them in a clinical context, to actually wake them up and make them functionally available for regeneration.That’s where our work begins.

What We Did at Cellomere

At Cellomere, we developed and published a method to activate these dormant cells using a non-invasive protocol.

In our recent study, we showed that after just 4.5 hours of cold enrichment, the number of viable small pluripotent cells in peripheral blood doubled. These cells expressed markers like OCT4, NANOG, SOX2, and SSEA-4, confirming their pluripotent nature.

But it gets better: These cells weren’t just more numerous — they were nucleated, viable, and metabolically active. And because they’re so small, they can be reintroduced into the body without getting stuck in lung capillaries, allowing for systemic therapeutic potential .

What Makes Our Approach Different?

• We developed a clinically applicable protocol to isolate and activate VSEL-like cells from peripheral blood — without genetic modification, culturing, or enzymes.

• We validated their pluripotency using immunofluorescent staining and nuclear verification.

• We can now measure, activate, and deliver these cells back to the body for targeted or systemic regeneration.

• All of this happens using autologous (your own) cells, in full compliance with FDA/EMA standards for minimal manipulation.

Why It Matters

Imagine the potential of using your own cells — no manipulation, no lab-grown expansion, no ethical hurdles — to:

• Support tissue regeneration

• Modulate chronic inflammation

• Improve recovery after injury

• Possibly even influence biological aging

That’s what we’re building. And we’re one of just a handful of clinics in the world to have published original data in this space.

Summary: What’s Inside You Is Already Extraordinary

You don’t need to import stem cells. You don’t need to reprogram them in a lab. You already have some of the most powerful regenerative cells in nature — inside your own body.

The only thing missing? A way to wake them up. And now, for the first time, we’ve shown that it’s possible.

📖 Want to learn more?

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Because the future of regenerative medicine isn’t synthetic. It’s already in your blood.